Disseminated Fusariosis Occurring in Two Patients Despite Posaconazole Prophylaxis
نویسندگان
چکیده
منابع مشابه
Disseminated fusariosis occurring in two patients despite posaconazole prophylaxis.
Posaconazole is widely used for prophylaxis against invasive fungal infections in patients undergoing myeloablative therapy. Disseminated fusariosis is a serious invasive mold infection in such patients. Preclinical and clinical studies indicate activity of posaconazole against Fusarium. We describe two cases of disseminated fusariosis that occurred despite posaconazole prophylaxis.
متن کاملDisseminated Fusarium Infections in Patients Receiving Posaconazole Prophylaxis: A Report of 2 Patients and Brief Review of the Literature
Corresponding Author: John Byrne Fournier M.D.Roger Williams Medical Center/Boston University School of Medicine, United States Tel: 401 456 2521 E-mail: [email protected] Abstract: Fusarium is a filamentous fungi that has emerged as a frequent cause of invasive infections in immunocompromised patients. Dermatologists often play a critical role in diagnosing fusariosis, as greater than 70...
متن کامل[Disseminated fusariosis during autologous stem cells transplant].
Fusarium is a filamentous brown fungus found in soil, on plants and outdoors responsible for localized or disseminated infections. Diagnosis is based on blood cultures and skin biopsy. Disseminated fusariosis is a rare and serious fungal infection, that occurs especially in neutropenic immunosuppressed patients. Treatment is difficult and mortality is estimated between 50 and 70% in adult patie...
متن کاملEfficacy of posaconazole as treatment and prophylaxis against Fusarium solani.
Invasive fusariosis is a highly aggressive fungal infection associated with high mortality in heavily immunocompromised patients. Although posaconazole is efficacious as salvage therapy against infections caused by Fusarium species, concerns remain regarding this agent in the setting of reduced potency. To evaluate the efficacy of posaconazole as treatment or prophylaxis against invasive fusari...
متن کاملPosaconazole as salvage treatment for invasive fusariosis in patients with underlying hematologic malignancy and other conditions.
BACKGROUND Conventional amphotericin B-based antifungal therapy for invasive fusariosis in patients with a hematologic malignancy results in a > or = 70% failure rate. Posaconazole is a broad-spectrum antifungal agent with in vitro and in vivo activity against Fusarium species. METHODS In this retrospective analysis of patients from 3 open-label clinical trials, we evaluated posaconazole for ...
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ژورنال
عنوان ژورنال: Journal of Clinical Microbiology
سال: 2011
ISSN: 0095-1137
DOI: 10.1128/jcm.02325-10